In his talk, Prof. Sourav Banerjee explored the intricate role of long non-coding RNAs (lncRNAs) in memory formation and synaptic plasticity. He discussed how synapse-enriched lncRNAs in the hippocampus regulate localized translation, a critical process for memory storage. Through his research, Prof. Banerjee revealed how these RNAs function as molecular decoys, modulating protein synthesis at synapses and thereby influencing cognitive functions.
The talk further delved into the role of specific lncRNAs, such as SynLAMP, with findings showing that its knockdown led to impaired fear memory. Prof. Banerjee also discussed how sleep deprivation affects the expression of these RNAs, ultimately disrupting ATP metabolism and cognitive performance. Additionally, he shared insights into the potential therapeutic application of Cerox1, noting that its overexpression could mitigate memory deficits induced by sleep deprivation.
Title: : Long Non-Coding RNAs in Regulation of Memory.
Speaker: Prof. Sourav Banerjee (National Brain Research Center (NBRC), India).
Venue: Seminar Hall B, Ground floor, Biosciences and Bioengineering Department, IIT Bombay.
Date: 3rd March 2025
Time: 9.30 AM